An interdisciplinary expert-led webinar on Tobacco Harm Reduction (THR) took place on Thursday, 27 April. The webinar brought together a distinguished panel of experts from four countries, sharing knowledge and expertise on THR, from the perspective of public health, policy, and advocacy. The panel of speakers discussed the concept of THR, the framework of evidence that supports it as a strategy for smoking cessation, and the challenges and opportunities in implementing THR strategies in the region.